Bitter Taste Receptors: an Answer to Comprehensive Asthma Control?
Identifieur interne : 000994 ( Main/Exploration ); précédent : 000993; suivant : 000995Bitter Taste Receptors: an Answer to Comprehensive Asthma Control?
Auteurs : Ajay P. Nayak [États-Unis] ; Dominic Villalba [États-Unis] ; Deepak A. Deshpande [États-Unis]Source :
- Current allergy and asthma reports [ 1529-7322 ] ; 2019.
Abstract
Asthma is marked by peculiar pathological features involving airway contraction, an impinging inflammation in the lungs, and an inexorably progressive remodeling of pulmonary architecture. Current medications for management of asthma exacerbations fail to optimally mitigate these pathologies, which is partly due to the intrinsic heterogeneity in the development and progression of asthma within different populations. In recent years, the discovery of the ectopic expression of TAS2Rs in extraoral tissues and different cell types, combined with significant strides in gaining mechanistic understanding into receptor signaling and function, has revealed the potential to target TAS2Rs for asthma relief.
TAS2R activation leads to relaxation of airway smooth muscle cells and bronchodilation. In addition, findings from preclinical studies in murine model of asthma suggest that TAS2R agonists inhibit allergen-induced airway inflammation, remodeling, and hyperresponsiveness.
In this review, we expand on the opportunity presented by TAS2Rs in the development of a comprehensive asthma treatment that overcomes the limitations set forth by current asthma therapeutics.
Url:
DOI: 10.1007/s11882-019-0876-0
PubMed: 31486942
PubMed Central: 6765386
Affiliations:
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Nayak</name><affiliation wicri:level="1"><nlm:aff id="A1">Department of Medicine, Center for Translational Medicine and Division of Pulmonary, Allergy and Critical Care Medicine; and Jane & Leonard Korman Respiratory Institute, Thomas Jefferson University, Jefferson Alumni Hall, Room 543, 1020 Locust Street, Philadelphia, PA 19107, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, Center for Translational Medicine and Division of Pulmonary, Allergy and Critical Care Medicine; and Jane & Leonard Korman Respiratory Institute, Thomas Jefferson University, Jefferson Alumni Hall, Room 543, 1020 Locust Street, Philadelphia, PA 19107</wicri:regionArea><wicri:noRegion>PA 19107</wicri:noRegion></affiliation></author><author><name sortKey="Villalba, Dominic" sort="Villalba, Dominic" uniqKey="Villalba D" first="Dominic" last="Villalba">Dominic Villalba</name><affiliation wicri:level="1"><nlm:aff id="A1">Department of Medicine, Center for Translational Medicine and Division of Pulmonary, Allergy and Critical Care Medicine; and Jane & Leonard Korman Respiratory Institute, Thomas Jefferson University, Jefferson Alumni Hall, Room 543, 1020 Locust Street, Philadelphia, PA 19107, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, Center for Translational Medicine and Division of Pulmonary, Allergy and Critical Care Medicine; and Jane & Leonard Korman Respiratory Institute, Thomas Jefferson University, Jefferson Alumni Hall, Room 543, 1020 Locust Street, Philadelphia, PA 19107</wicri:regionArea><wicri:noRegion>PA 19107</wicri:noRegion></affiliation></author><author><name sortKey="Deshpande, Deepak A" sort="Deshpande, Deepak A" uniqKey="Deshpande D" first="Deepak A." last="Deshpande">Deepak A. Deshpande</name><affiliation wicri:level="1"><nlm:aff id="A1">Department of Medicine, Center for Translational Medicine and Division of Pulmonary, Allergy and Critical Care Medicine; and Jane & Leonard Korman Respiratory Institute, Thomas Jefferson University, Jefferson Alumni Hall, Room 543, 1020 Locust Street, Philadelphia, PA 19107, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, Center for Translational Medicine and Division of Pulmonary, Allergy and Critical Care Medicine; and Jane & Leonard Korman Respiratory Institute, Thomas Jefferson University, Jefferson Alumni Hall, Room 543, 1020 Locust Street, Philadelphia, PA 19107</wicri:regionArea><wicri:noRegion>PA 19107</wicri:noRegion></affiliation></author></analytic><series><title level="j">Current allergy and asthma reports</title><idno type="ISSN">1529-7322</idno><idno type="eISSN">1534-6315</idno><imprint><date when="2019">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="S1"><title>Purpose of Review</title><p id="P1">Asthma is marked by peculiar pathological features involving airway contraction, an impinging inflammation in the lungs, and an inexorably progressive remodeling of pulmonary architecture. Current medications for management of asthma exacerbations fail to optimally mitigate these pathologies, which is partly due to the intrinsic heterogeneity in the development and progression of asthma within different populations. In recent years, the discovery of the ectopic expression of TAS2Rs in extraoral tissues and different cell types, combined with significant strides in gaining mechanistic understanding into receptor signaling and function, has revealed the potential to target TAS2Rs for asthma relief.</p></sec><sec id="S2"><title>Recent Findings</title><p id="P2">TAS2R activation leads to relaxation of airway smooth muscle cells and bronchodilation. In addition, findings from preclinical studies in murine model of asthma suggest that TAS2R agonists inhibit allergen-induced airway inflammation, remodeling, and hyperresponsiveness.</p></sec><sec id="S3"><title>Summary</title><p id="P3">In this review, we expand on the opportunity presented by TAS2Rs in the development of a comprehensive asthma treatment that overcomes the limitations set forth by current asthma therapeutics.</p></sec></div></front></TEI><affiliations><list><country><li>États-Unis</li></country></list><tree><country name="États-Unis"><noRegion><name sortKey="Nayak, Ajay P" sort="Nayak, Ajay P" uniqKey="Nayak A" first="Ajay P." last="Nayak">Ajay P. Nayak</name></noRegion><name sortKey="Deshpande, Deepak A" sort="Deshpande, Deepak A" uniqKey="Deshpande D" first="Deepak A." last="Deshpande">Deepak A. Deshpande</name><name sortKey="Villalba, Dominic" sort="Villalba, Dominic" uniqKey="Villalba D" first="Dominic" last="Villalba">Dominic Villalba</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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